CAVER is a software tool for analysis and visualization of tunnels and channels in protein structures. Tunnels are void pathways leading from a cavity buried in a protein core to the surrounding solvent. Unlike tunnels, channels lead through the protein structure and their both endings are opened to the surrounding solvent. Studying of these pathways is highly important for drug design and molecular enzymology.

CAVER Analyst

CAVER provides rapid, accurate and fully automated calculation of tunnels and channels in static and dynamic structures. The molecules amendable to analysis of CAVER include proteins, nucleic acids, or inorganic materials.

The software is available as CAVER 3.0 command-line version, CAVER 3.0 PyMol plugin or graphical application CAVER Analyst 1.0. The latest version of CAVER enables the analysis of molecular dynamics simulations. CAVER Analyst allows easy set-up of calculation, visualization of results, and efficient visual analysis of data.

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451 citations
5716 registered users
60872x CAVER downloaded


June 20, 2016

CAVER was cited in Nature in the article Crystal structure of the epithelial calcium channel TRPV6.

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CAVER was cited in Nature Communications in the article A CD36 ectodomain mediates insect pheromone...

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April 26, 2016

CAVER was cited in the Cell Structure journal in the article A Gating Mechanism of the Serotonin...

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