CAVER is a software tool for analysis and visualization of tunnels and channels in protein structures. Tunnels are void pathways leading from a cavity buried in a protein core to the surrounding solvent. Unlike tunnels, channels lead through the protein structure and their both endings are opened to the surrounding solvent. Studying of these pathways is highly important for drug design and molecular enzymology.

CAVER Analyst

CAVER provides rapid, accurate and fully automated calculation of tunnels and channels in static and dynamic structures. The molecules amendable to analysis of CAVER include proteins, nucleic acids, or inorganic materials.

The software is available as CAVER 3.0 command-line version, CAVER 3.0 PyMol plugin or graphical application CAVER Analyst 1.0. The latest version of CAVER enables the analysis of molecular dynamics simulations. CAVER Analyst allows easy set-up of calculation, visualization of results, and efficient visual analysis of data.

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451 citations
5741 registered users
62774x CAVER downloaded


August 16, 2016

CAVER was cited in the NATURE journal in article Structure of mammalian respiratory complex I.

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August 10, 2016

CAVER was cited in Nature in the article Structural basis of Smoothened regulation by its...

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August 10, 2016

CAVER was cited in the Journal of Biological Chemistry in the article Structural plasticity of...

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