CAVER is a software tool for analysis and visualization of tunnels and channels in protein structures. Tunnels are void pathways leading from a cavity buried in a protein core to the surrounding solvent. Unlike tunnels, channels lead through the protein structure and their both endings are opened to the surrounding solvent. Studying of these pathways is highly important for drug design and molecular enzymology.

CAVER Analyst

CAVER provides rapid, accurate and fully automated calculation of tunnels and channels in static and dynamic structures. The molecules amendable to analysis of CAVER include proteins, nucleic acids, or inorganic materials.

The software is available as CAVER 3.0 command-line version, CAVER 3.0 PyMol plugin or graphical application CAVER Analyst 1.0. The latest version of CAVER enables the analysis of molecular dynamics simulations. CAVER Analyst allows easy set-up of calculation, visualization of results, and efficient visual analysis of data.

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451 citations
5761 registered users
64904x CAVER downloaded


October 18, 2016

CAVER was cited in the Journal of Biological Chemistry in the article Structure of the Catalytic...

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CAVER was cited in the ACS Catalysis journal in article Evolution of P450 Monooxygenases toward...

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August 16, 2016

CAVER was cited in the NATURE journal in article Structure of mammalian respiratory complex I.

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